|
Symbol Name ID |
Tardbp
TAR DNA binding protein MGI:2387629 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hyposmia |
Dysphagia |
Spasticity |
Fatigable weakness of bulbar muscles |
Fatigable weakness of swallowing muscles |
Fatigable weakness of respiratory muscles |
Motor neuron atrophy |
Amyotrophic lateral sclerosis |
Neurodegeneration |
Bradykinesia |
Fasciculations |
Tremor |
Paralysis |
Babinski sign |
Dysarthria |
Language impairment |
Depression |
Emotional lability |
Anxiety |
Panic attack |
Hallucinations |
Perseverative thought |
Atypical behavior |
Apathy |
Reduced social reciprocity |
Disinhibition |
Impulsivity |
Agitation |
Restless legs |
Motor stereotypy |
Cognitive impairment |
Dementia |
Frontal lobe dementia |
Frontotemporal dementia |
Short attention span |
Sleep abnormality |
Insomnia |
Hyperreflexia |
Jaw hyperreflexia |
Dyskinesia |
Dystonia |
Gait imbalance |
Postural instability |
Abnormal autonomic nervous system physiology |
| Disease(s) Associated with TARDBP | ||||||||||||||||||||||||||||||||||||||||||||
| amyotrophic lateral sclerosis | ||||||||||||||||||||||||||||||||||||||||||||
| amyotrophic lateral sclerosis type 10 | ||||||||||||||||||||||||||||||||||||||||||||
| Parkinson's disease |
| Mouse Phenotypes | nervous system phenotype |
increased neuron apoptosis |
microgliosis |
increased microglial cell activation |
abnormal brain interneuron morphology |
decreased brain weight |
decreased hippocampus volume |
abnormal cerebral cortex morphology |
abnormal primary motor cortex morphology |
abnormal frontal lobe morphology |
astrocytosis |
gliosis |
abnormal motor neuron innervation pattern |
abnormal neuron morphology |
abnormal GABAergic neuron morphology |
abnormal motor neuron morphology |
decreased motor neuron number |
motor neuron degeneration |
abnormal axon morphology |
decreased neuron number |
abnormal neuromuscular synapse morphology |
neuronal cytoplasmic inclusions |
abnormal spinal cord ventral horn morphology |
neurodegeneration |
axon degeneration |
reduced long-term potentiation |
abnormal miniature excitatory postsynaptic currents |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||
| Tardbpem1Koya/Tardbpem1Koya | * | |||||||||||||||||||||||||||
| Tardbpem1Rhbr/Tardbpem1Rhbr | * | |||||||||||||||||||||||||||
| TardbpRgsc2223/TardbpRgsc2223 | ||||||||||||||||||||||||||||
| Tardbptm1.1Neas/Tardbptm1.1Neas | * | |||||||||||||||||||||||||||
| Tardbptm2.1Neas/Tardbptm2.1Neas | * | |||||||||||||||||||||||||||
| Tg(Camk2a-Tardbp)#Ckjs/Tg(Camk2a-Tardbp)#Ckjs | ||||||||||||||||||||||||||||
| Tardbpm1H/Tardbp+ | * | |||||||||||||||||||||||||||
| Tardbptm1.1Hiok/Tardbp+ | ||||||||||||||||||||||||||||
| Tardbptm1.1Neas/Tardbp+ | * | |||||||||||||||||||||||||||
| Tardbptm2.1Neas/Tardbp+ | * | |||||||||||||||||||||||||||
| Tardbptm3.1Ckjs/Tardbp+ | ||||||||||||||||||||||||||||
| Tardbptm3.1Ckjs/Tardbp+ Tg(Hlxb9-GFP)1Tmj/0 |
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| Tg(CAG-dsRed2/RNAi:Tardbp)6Zxu/0 | ||||||||||||||||||||||||||||
| Tardbptm1.1Sobue/Tardbptm1.1Sobue Tg(SLC18A3-cre)Misa/0 (conditional) |
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| Mnx1tm4(cre)Tmj/Mnx1+ Tardbptm1.1Ckjs/Tardbptm1.2Cjks (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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